The Calgary Guide to Understanding Disease @TheCalgaryGuide
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diagnosis psychiatry behavioraldisorder mooddisorders vasculitis affectivedisorder arteritis attentiondeficithyperactivedisorder benign bipolar bph cd compartmentsyndrome conduct disease disorder endocrinology feedbackloop gh giantcell
Chronic Exertional Compartment Syndrome (CECS) • Diagnosis Of CECS requires patient to undergo the same exertional
• Diagnostic criteria ... pressure 0-4 mmHg #ChronicExertional ... #pathophysiology ... #diagnosis #signs ... #symptoms #msk
Major Depressive Disorder (MDD): Pathogenesis and Clinical Findings Symptoms (included in DSM 5 criteria) - Present during
Major Depressive ... included in DSM 5 criteria ... MajorDepressiveDisorder #Depression ... MoodDisorders #Diagnosis #Pathophysiology ... #Signs #Symptoms
Attention Deficit Hyperactive Disorder (ADHD): Pathogenesis and clinical findings - For diagnosis, must have either 26
have either 26 symptoms ... 2 settings - Symptoms ... BehavioralDisorder #Pathophysiology ... #signs #psychiatry ... #criteria
Giant Cell (Temporal) Arteritis: Pathogenesis and investigations Risk Factors: - Unclear environmental triggers (may be viral, not
inflammatory cytokine expression ... yrs old; F>M Signs ... /Symptoms: - Fever ... Temporal #Arteritis #Pathophysiology ... #Diagnosis #Signs
Schizophrenia: Pathogenesis and Symptoms Increased dopaminergic transmission in mesolimbic projection -> Dopaminergic neurons here project into the limbic
Pathogenesis and Symptoms ... cause the Positive Symptoms ... Diminished emotional expression ... Schizophrenia #pathophysiology ... #signs #psychiatry
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
pathway -> Incr gene expression ... activates lipolysis Signs ... /Symptoms: • GH ... endocrinology #pathophysiology
Glucocorticoid-Induced Osteoporosis: Pathogenesis and Clinical Findings • Negative feedback on hypothalamus/pituitary, Decreasing ACTH -> Decr Sex
Upregulate gene expression ... #Osteoporosis #pathophysiology ... #signs #symptoms
Xeropthalmia: Pathogenesis and Ocular Manifestations Decr Visual pigment -> Keratinization, thickening & non-wetting of the conjunctiva
& Decr surface expression ... #Xeropthalmia #pathophysiology ... ophthalmology #diagnosis #signs ... #symptoms
Seasonal Affective Disorder: Pathogenesis and clinical findings Symptoms (included in the DSM-V) - Two Major Depressive episodes
clinical findings Symptoms ... DSM-V) - Two Major Depressive ... season at work) Symptoms ... MoodDisorders #Diagnosis #Pathophysiology ... #Signs #Symptoms
Bipolar Disorder: Pathogenesis and Clinical Findings • Disruption of emotional homeostasis • Oscillation between mood states
maintain this state Depressive ... MoodDisorders #Diagnosis #Pathophysiology ... #Signs #Symptoms
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