The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Pathogenesis of Anxiety Disorders

Anxiety Disorders: A maladaptive emotional state causing fear,
worry, and excessive stress, characterized by:
Disorders Anxiety ... Disorders: A maladaptive ... greater reporting rates ... #Disorders #Pathophysiology ... #diagnosis #psychiatry
Classification of Pelvic Ring Fractures: Mechanisms, Clinical Features and Complications
 • Anterior Posterior Compression (APC) -
cyclist) - APC Grade ... 2.5cm - APC Grade ... #Orthopedics #MSK ... #diagnosis #complications ... #pathophysiology
Post-Traumatic Stress Disorder (PTSD)
Neurochemical abnormalities
 • Hyper-vigilance
 • Emotional hyper-arousal
 • Exaggerated startle reflex
 • Anxiety
Post-Traumatic Stress Disorder ... startle reflex • Anxiety ... BehavioralDisorder #Pathophysiology ... #diagnosis #symptoms
Serotonin-Norepinephrine Reuptake Inhibitors(SNRIs): Mechanisms and Side Effects

Withdrawal: Dizziness, Diarrhea, Insomnia, Nausea, Vomiting
Serotonin Syndrome - Potentially Life
Diarrhea, Insomnia, Nausea ... gain Incr NE: Nausea ... SerotoninNorepinephrine #Inhibitors #Pathophysiology ... #Pharmacology #SideEffects ... #Psychiatry #Diagnosis
Selective Serotonin Reuptake Inhibitors: Mechanisms and Side Effects
 • Serotonin Syndrome:
   - Autonomic Hyperactivity:
Dizziness - Nausea ... Serotonin #Inhibitors #Pathophysiology ... #Pharmacology #SideEffects ... #Psychiatry #Diagnosis
Anticonvulsants as Mood Stabilizers: Mechanism and Side-effect
Examples: Valproate, Carbamazepine, Lamotrigine
 • Mild anticholinergic effect -> Drowsiness
relapse of bipolar disorder ... Systemic effect -> Nausea ... MoodStabilizers #Mechanism #SideEffects ... #Pathophysiology
Alcohol Use Disorder: Pathogenesis and Clinical Findings

 • Tolerance (reduced sensitivity to effects of EtOH)
 •
Alcohol Use Disorder ... , tachycardia, nausea ... , seizure, and anxiety ... AlcoholUseDisorder #EtOH #Pathophysiology ... #Diagnosis #Signs
Major Depressive Disorder (MDD): Pathogenesis and Clinical Findings

Symptoms (included in DSM 5 criteria) - Present during
Major Depressive Disorder ... Seasonal Affective Disorder ... partum onset) - Anxiety ... MoodDisorders #Diagnosis ... #Pathophysiology
Bipolar Disorder: Pathogenesis and Clinical Findings
 • Disruption of emotional homeostasis
 • Oscillation between mood states
Bipolar Disorder ... - Incr guilt, anxiety ... behaviours #Bipolar #Disorder ... MoodDisorders #Diagnosis ... #Pathophysiology
Low Ankle Sprain: Pathomechanics and Clinical Findings

Grading Ligament Sprains
l: Minimal ligament disruption, mild swelling & tenderness,
LowAnkleSprain #Sports #MSK ... orthopedics #Grading #Grades ... #Diagnosis #pathophysiology