The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Selective Serotonin Reuptake Inhibitors: Mechanisms and Side Effects
 • Serotonin Syndrome:
   - Autonomic Hyperactivity:
#SideEffects #Psychiatry ... #Diagnosis #Signs
Post-Traumatic Stress Disorder (PTSD)
Neurochemical abnormalities
 • Hyper-vigilance
 • Emotional hyper-arousal
 • Exaggerated startle reflex
 • Anxiety
Pathophysiology #diagnosis ... symptoms #signs #psychiatry
Serotonin-Norepinephrine Reuptake Inhibitors(SNRIs): Mechanisms and Side Effects

Withdrawal: Dizziness, Diarrhea, Insomnia, Nausea, Vomiting
Serotonin Syndrome - Potentially Life
#SideEffects #Psychiatry ... #Diagnosis #Signs
Pathogenesis of Anxiety Disorders

Anxiety Disorders: A maladaptive emotional state causing fear,
worry, and excessive stress, characterized by:
Pathophysiology #diagnosis ... #psychiatry
Obsessive-Compulsive Disorder (OCD): Pathogenesis and clinical findings

Psychological Hypothesis
 • Cognitive behavioral model: Emotional disturbance arising from
PersonalityDisorder #Diagnosis ... #Psychiatry #Signs
Third Generation Antipsychotics: Mechanisms and Side Effects
(Atypical Anti-Psychotics) Example: Aripiprazole
Dopamine D2 Receptor Partial Agonist
 • Binds
#pharmacology #diagnosis ... #psychiatry
Alcohol Use Disorder: Pathogenesis and Clinical Findings

 • Tolerance (reduced sensitivity to effects of EtOH)
 •
Pathophysiology #Diagnosis ... Signs #Symptoms #Psychiatry
Major Depressive Disorder (MDD): Pathogenesis and Clinical Findings

Symptoms (included in DSM 5 criteria) - Present during
MoodDisorders #Diagnosis ... Signs #Symptoms #Psychiatry
Bipolar Disorder: Pathogenesis and Clinical Findings
 • Disruption of emotional homeostasis
 • Oscillation between mood states
MoodDisorders #Diagnosis ... Signs #Symptoms #Psychiatry
Schizophrenia: Pathogenesis and Symptoms
Increased dopaminergic transmission in mesolimbic projection
-> Dopaminergic neurons here project into the limbic
pathophysiology #diagnosis ... symptoms #signs #psychiatry