The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Major Depressive Disorder (MDD): Pathogenesis and Clinical Findings

Symptoms (included in DSM 5 criteria) - Present during
Major Depressive ... included in DSM 5 criteria ... MoodDisorders #Diagnosis ... #Pathophysiology ... #Psychiatry
Selective Serotonin Reuptake Inhibitors: Mechanisms and Side Effects
 • Serotonin Syndrome:
   - Autonomic Hyperactivity:
Serotonin #Inhibitors #Pathophysiology ... #Pharmacology #SideEffects ... #Psychiatry #Diagnosis ... #Signs #Symptoms
Serotonin-Norepinephrine Reuptake Inhibitors(SNRIs): Mechanisms and Side Effects

Withdrawal: Dizziness, Diarrhea, Insomnia, Nausea, Vomiting
Serotonin Syndrome - Potentially Life
SerotoninNorepinephrine #Inhibitors #Pathophysiology ... #Pharmacology #SideEffects ... #Psychiatry #Diagnosis ... #Signs #Symptoms
Schizophrenia: Pathogenesis and Symptoms
Increased dopaminergic transmission in mesolimbic projection
-> Dopaminergic neurons here project into the limbic
Pathogenesis and Symptoms ... Diminished emotional expression ... Schizophrenia #pathophysiology ... #diagnosis #symptoms ... #signs #psychiatry
Post-Traumatic Stress Disorder (PTSD)
Neurochemical abnormalities
 • Hyper-vigilance
 • Emotional hyper-arousal
 • Exaggerated startle reflex
 • Anxiety
BehavioralDisorder #Pathophysiology ... #diagnosis #symptoms ... #signs #psychiatry
Seasonal Affective Disorder: Pathogenesis and clinical findings

Symptoms (included in the DSM-V) - Two Major Depressive episodes
clinical findings Symptoms ... MoodDisorders #Diagnosis ... #Pathophysiology ... #Signs #Symptoms ... #Psychiatry
Bipolar Disorder: Pathogenesis and Clinical Findings
 • Disruption of emotional homeostasis
 • Oscillation between mood states
maintain this state Depressive ... MoodDisorders #Diagnosis ... #Pathophysiology ... #Signs #Symptoms ... #Psychiatry
Attention Deficit Hyperactive Disorder (ADHD): Pathogenesis and clinical findings
 - For diagnosis, must have either 26
findings - For diagnosis ... BehavioralDisorder #Pathophysiology ... #diagnosis #symptoms ... #signs #psychiatry ... #criteria
Giant Cell (Temporal) Arteritis: Pathogenesis and investigations
Risk Factors:
 - Unclear environmental triggers (may be viral, not
inflammatory cytokine expression ... old; F>M Signs/Symptoms ... Temporal #Arteritis #Pathophysiology ... #Diagnosis #Signs ... #Symptoms #Vasculitis
Alcohol Use Disorder: Pathogenesis and Clinical Findings

 • Tolerance (reduced sensitivity to effects of EtOH)
 •
• Withdrawal symptoms ... AlcoholUseDisorder #EtOH #Pathophysiology ... #Diagnosis #Signs ... #Symptoms #Psychiatry