The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Bipolar Disorder: Pathogenesis and Clinical Findings
 • Disruption of emotional homeostasis
 • Oscillation between mood states
variability in disease ... Bipolar #Disorder #MoodDisorders ... #Diagnosis #Pathophysiology ... #Signs #Symptoms ... #Psychiatry
Major Depressive Disorder (MDD): Pathogenesis and Clinical Findings

Symptoms (included in DSM 5 criteria) - Present during
MajorDepressiveDisorder #Depression #MoodDisorders ... #Diagnosis #Pathophysiology ... #Signs #Symptoms ... #Psychiatry
Selective Serotonin Reuptake Inhibitors: Mechanisms and Side Effects
 • Serotonin Syndrome:
   - Autonomic Hyperactivity:
Serotonin #Inhibitors #Pathophysiology ... #SideEffects #Psychiatry ... #Diagnosis #Signs
Osteoporosis: Pathogenesis and risk factors

 • Age > 30 (post-peak bone mass)
 • Post-menopausal women ->
Leukemia) • GI diseases ... liver or kidney disease ... #Osteoporosis #pathophysiology ... #signs #symptoms ... #diagnosis
Post-Traumatic Stress Disorder (PTSD)
Neurochemical abnormalities
 • Hyper-vigilance
 • Emotional hyper-arousal
 • Exaggerated startle reflex
 • Anxiety
BehavioralDisorder #Pathophysiology ... #diagnosis #symptoms ... #signs #psychiatry
Serotonin-Norepinephrine Reuptake Inhibitors(SNRIs): Mechanisms and Side Effects

Withdrawal: Dizziness, Diarrhea, Insomnia, Nausea, Vomiting
Serotonin Syndrome - Potentially Life
SerotoninNorepinephrine #Inhibitors #Pathophysiology ... #SideEffects #Psychiatry ... #Diagnosis #Signs
Graves’ Disease: Pathogenesis and Clinical Findings
B & T lymphocyte mediated autoimmunity attack TSH receptor -> Continuous
Graves’ Disease: ... the etiology Signs ... GravesDisease #pathophysiology ... endocrinology #symptoms #signs ... #diagnosis
Alcohol Use Disorder: Pathogenesis and Clinical Findings

 • Tolerance (reduced sensitivity to effects of EtOH)
 •
AlcoholUseDisorder #EtOH #Pathophysiology ... #Diagnosis #Signs ... #Symptoms #Psychiatry
Alzheimer’s Disease: Pathogenesis and Clinical Findings
Risk factor for Late Onset Alzheimer's (99% of cases):
 - Increasing
Alzheimer’s Disease ... chromosome 21) Signs ... AlzheimersDisease #Dementia #pathophysiology ... #geriatrics #diagnosis ... #signs #symptoms
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings
• Primary Sjögren's is a solitary process whereas secondary Sjögren's
other autoimmune diseases ... with systemic diseases ... erythematosus (SLE) Signs ... Sjogrens #Syndrome #Pathophysiology ... #Diagnosis #Signs