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diagnosis rheumatology cardiology causes pain erythematosus regurgitation sle arthritis dermatology msk primary systemic algorithm aortic approach clues comparison conditions extrarticular
Primary and Secondary Causes of Mitral Regurgitation Primary (organic) chronic mitral regurgitation: • Leaflet: Rheumatic fever, Infective
, Infective endocarditis ... , Infective endocarditis ... annulus valve: ... cardiomyopathy - VA Joint ... Regurgitation #differential
Causes of Severe Aortic Regurgitation - Differential Diagnosis Acute: • Leaflet: Traumatic Rupture, Acute Infective Endocarditis, Acute
Endocarditis, Acute ... Prosthetic Valve ... : Infective Endocarditis ... , Rheumatic Fever ... Inflammatory: Lupus
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Features of Systemic Lupus ... (SLE) General: Fever ... phenomenon (20%) Joints ... Pericarditis, Endocarditis ... , Aortic valve lesions
Approach to Joint Pain - Diagnostic Framework 1) Chronicity 2) Inflammatory vs Non-Inflammatory 3) Number of Joints Involved 1) Chronicity:
acute rheumatic fever ... spondyloarthropathies, lupus ... infection. ... #rheumatology # ... approach #workup #differential
Extra-articular and Other Conditions Associated with Joint Pain Eyes • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
infection • ... Subacute bacterial endocarditis ... infection, Amyloidosis ... - Bacterial endocarditis ... #pain #differential
Myositis and Myopathies Polymyositis • Progressive, symmetric muscle weakness • Elevated CK, +Anti-Jo, +Anti-Mi2 Dermatomyositis
, Fever, No muscle ... Detectable HIV viral ... Anti-retrovirals, Gemcitabine Lupus ... uncommon 5-15% of lupus ... Myopathies #myopathy #differential
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
Associated with Joint ... parvovirus B19 infection ... • Rheumatic fever ... lesions • Discoid lupus ... #rashes #differential
Causes of Fever of Unknown Origin (FUO) - Differential Diagnosis • Infection: Extrapulmonary tuberculosis, Abscess, Endocarditis,
Origin (FUO) - Differential ... Diagnosis • Infection ... tuberculosis, Abscess, Endocarditis ... Malignancy: - Hematologic ... . autoimmune): Lupus
Causes of Thrombocytopenia - Differential Diagnosis Framework Decreased Production: - Drugs (chemo, yang, sulfa, acetaminophen, NSAIDs, quinine,
quinine, etc) - Viral ... infiltration: malignancy, infection ... - Mechanical: valve ... replacement, endocarditis ... Diagnosis #Framework #hematology
Top 10 situations when to think about lupus 1) Inflammatory joint pain (especially in the wrists and
) Inflammatory joint ... the face (many differential ... ; sometimes « viral ... 9) Unexplained fever ... , when infection
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