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diagnosis differential hematology anemia extravascular hemolysis management abnormal bleeding blood bruising coagulation color dic discoloration disseminated dm2 elevation endocrinology false
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Causes Intravascular ... HUS) • Other: Transfusion ... G6PD deficiency) ... #Hemolytic #Intravascular ... #Causes #differential
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... Diagnosis Algorithm ... Defects • G6PD deficiency ... • PK deficiency ... #Causes #Hematology
Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12,
Causes of False ... -12, or folate deficiency ... Content • RBC Transfusions ... blood loss • Hemolytic ... #Decrease #Diagnosis
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
Differential Diagnosis Algorithm ... DAT (-) → G6PD Deficiency ... disease, drugs, transfusions ... Differential #Diagnosis #Algorithm ... #causes
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Transfusion Thresholds ... recipients w/ IgA deficiency ... Causes purpura & ... TRALI): Leading cause ... more likely to cause
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... Decreased WBCs ... - Decreased/NormaI ... • Early Iron Deficiency ... #Causes #Hematology
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Causes of Bleeding ... Differential Diagnosis Algorithm ... Quantitative Defect • Decreased ... • Disseminated Intravascular ... #Causes #Hematology
Causes of Iron Deficiency - Differential Diagnosis Algorithm • Blood loss: GI (cancer, ulcer, IBD), GU
Causes of Iron Deficiency ... • Iron loss: Intravascular ... hemolysis, (PNH ... MALABSORPTION • Decreased ... #Fe #algorithm
Hyperphosphatemia - Differential Diagnosis Algorithm Transcellular Shift: • Rhabdomyolysis • Tumor Lysis • Metabolic or Respiratory Acidosis
Differential Diagnosis Algorithm ... Acidosis • Insulin Deficiency ... Decreased Excretion ... Hyperbilirubinemia • Hemolysis ... endocrinology #causes
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... incompatible blood transfusion ... thrombopoietin deficiency ... Treat primary cause ... #Disseminated #Intravascular
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