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diagnosis nephrology differential rheumatology clinical classification management pulmonary vasculitis workup algorithm causes erythematosus glomerulonephritis hematology injury lupus sle acute aki
Effect of Selected Diseases on Complement Levels - C3, C4 • SLE C3 ↓ C4 ↓↓
• SLE C3 ↓ C4 ... MCGN type 1 C3 ↓ C4 ... ↓↓ • Cryo C3 ... angiooedema C3 C4 ... • C3GN C3 ↓ C4
Glomerulonephritis - Differential Diagnosis Framework ANCA: • C-ANCA: GPA (Wegener's) • P-ANCA: Microscopic Polyangiitis, Eosinophilic GPA (Churg
Membranoproliferative • ↓C4 ... Cryoglobulinemia • Normal C3/C4
Subtypes of Serum Proteins Pre-albumin (Transthyretin) Albumin Globulins • Alpha-1: Alpha-1 antitrypsin, Serum amyloid A, Ceruloplasmin, Corticosteroid-binding globulin (Transcortin),
• Beta: C3 and C4
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
Low C3 or low C4 ... Low C3 and low C4
Acute Kidney Injury (AKI) - Differential Diagnosis Framework Pre-Renal: • Hypovolemia, Cardiorenal, Distributive Shock, HRS, Hypercalcemia, Renal
, Anti-GBM, C3/C4
Formation of Trunks and Cords of the Brachial Plexus The spinal nerves of segments C5 – Th1
also of segments C4
Diagnosis and Management of Hypocomplementemic Urticarial Vasculitis (HUV) Diagnosis of HUV 1) Chronic urticaria 2) Leukocytoclastic vasculitis 3)
Hypocomplementemia (C3 and/or C4
Renal involvement in 35% of mixed cryoglobulinemia vasculitis Associated with : • Absence of skin
decr of C3 and C4
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
anti-GBM ab, ANA, C3, C4
Spinal Cord Injury by Nerve Root Levels Spinal Root Sensory Motor Reflex C4 Acromioclavicular Joint Respiration None C5 Radial Antecubital Fossa Elbow Flexion Biceps Reflex C6 Dorsal Thumb Wrist Extension Brachioradialis Reflex C7 Dorsal
Motor Reflex C4
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