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diagnosis differential treatment hematology nephrology algorithm sle classification criticalcare erythematosus hypercalcemia pharmacology systemic high hypertension oncology pediatrics vasculitis acute aki
Hypertension and Altered Mental Status (AMS) - Differential Diagnosis Framework Hypertension: • Hypertensive emergency • Hypertensive encephalopathy
Pre-Eclampsia Renal ... Acute/Chronic renal ... failure • Renal ... Vasculitis • Lupus ... • Scleroderma renal
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... antiphospholipid syndrome ... S - Systemic Lupus ... Erythematosus (total 50, renal ... #differential #hematology
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... severe disease & renal ... #Systemic #Lupus ... Summary #diagnosis #rheumatology ... #management
Hydroxychloroquine Serum Measurement in SLE • Terminal elimination half-life = 40 days ([HCQI reflects long-term intake)
• Special cases ... (e.g. renal failure ... Measurement #SLE #rheumatology ... pharmacology #levels #lupus ... #management
Causes of Acute Kidney Injury (AKI) - Differential Diagnosis Algorithm Acute Kidney Injury (AKI) - Acute increase
Causes of Acute ... at least 50% Renal ... • Hepatorenal syndromes ... IgA, post-strep, lupus ... Sjögren) Post-Renal
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
) • Systemic lupus ... • Sjögren syndrome ... polyangiitis without renal ... ANCA+ 30-60% • Renal-limited ... antibodies #diagnosis #rheumatology
Causes of Hypercalcemia Parathyroid hormone–dependent Primary hyperparathyroidism Familial hypocalciuric hypercalcemia Lithium-associated Tertiary hyperparathyroidism Genetic disorders (e.g., multiple endocrine neoplasia type 1 or
Causes of Hypercalcemia ... hormone–independent Renal ... Other humoral syndromes ... Hypercalcemia #Causes ... Differential #Diagnosis #Endocrinology
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 Causes of Hypercalcemia Hypercalcemia due to increased bone Ca2+ resorption: • Primary hyperparathyroidism, Malignancy, Pseudohyperparathyroidism, Renal failure,
Causes of Hypercalcemia ... Pseudohyperparathyroidism, Renal ... calcium)-alkali syndrome ... Hypercalcemia #Causes ... calcium #high #endocrinology
Common causes of Acute Kidney Injury AKI - Differential Diagnosis HEMODYNAMIC • Cardiac failure: Impaired forward flow,
Common causes of ... inhibitors, hepatorenal syndrome ... thromboembolism, renal ... tumors INTRINSINC RENAL ... Post-infectious GN, Lupus
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Features of Systemic Lupus ... Demyelinating syndromes ... Abdominal pain (20%) Renal ... Thrombocytopenia #Lupus ... symptoms #diagnosis #rheumatology
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