18 results
Lupus Nephritis Primer
Class I - Minimal Mesangial
Class II - Mesangial Proliferative
Class Ill - Focal Proliferative
Class IV
MD @MithuRheu and ... Lupus #Nephritis #SLE ... #Classification ... differential #diagnosis #management ... #nephrology
Hydroxychloroquine Serum Measurement in SLE
 • Terminal elimination half-life = 40 days ([HCQI reflects long-term intake)
Measurement in SLE ... and probably < ... #rheumatology # ... pharmacology #levels ... #lupus #management
Management of Lupus Nephritis
Lupus nephritis (LN) in 10 to 40% of SLE
Hallmark = proteinuria 20.5 g/g
in 10 to 40% of SLE ... severity (ISN/RPS classification ... by 12 months Classification ... #rheumatology # ... nephrology
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns
Nuclear Patterns:
 • Homogeneous pattern: 
   -
Smith, Sm/RNP, Scl ... Scl100, Th/To, Scl ... body-like: - Neurologic ... ARUPConsult @ARUPLabs #ANA ... differential #diagnosis #rheumatology
Renal involvement in 35% of mixed cryoglobulinemia vasculitis 
Associated with : 
 • Absence of skin
Combined decr of C3 and ... /min • <60 mL/ ... Cryoglobulinemia #Vasculitis #Management ... #Rheumatology # ... Cryoglobulinemic #Nephrology
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus
Clinical Domains:
 • Constitutional domain: Fever
 • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... least 2 joints • Neurologic ... low C4, Low C3 and ... #Criteria #SLE ... Erythematosus #diagnosis #rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE ... Erythematosus #SLE ... #CNS #neurology ... #rheumatology # ... cerebritis #diagnosis #management
Vancomycin Associated Acute Kidney Injury

 • Drug induced acute kidney injury is generally defined as a
increase of 44 mol ... agents, the dose and ... Vancomycin #AKI #pharmacology ... toxicology #diagnosis #management ... #nephrology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Skin Disease Classification ... erythematosus (ACLE ... Non-autoimmune rheumatologic ... La, anti-Jo-1, SCL ... Erythematosus #Diagnosis #Rheumatology
Diuretics - Pharmacology

Thiazides diuretics:
 • Inhibit Na+ Cl- cotransporter in distal tubule
 • Chlorothiazide, Chlorthalidone, Indapamide,
Diuretics - Pharmacology ... + Cl- cotransporter ... + and water loss ... #Diuretics #Pharmacology ... #nephrology #conversion