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diagnosis causes hematology algorithm classification hemolytic medications deficiency hyperkalemia nephrology potassium pulmonary druginduced emesis high management oncology rheumatology table vomiting
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... infection) - Drugs ... (Beta lactam antibiotics ... Extravascular #Causes #differential ... diagnosis #hematology #anemia
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
- Differential ... -100): • Non-hemolytic ... , CKD • Hemolytic ... Orotic aciduria, Drugs ... #Differential #
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
Hemolytic Anemia ... - Differential ... → Sickle Cell anemia ... autoimmune disease, drugs ... #Anemia #Differential
Differential diagnosis of schistocytes / fragmentation hemolysis: • Thrombotic microangiopathies (TMA) - TTP
Differential diagnosis ... fragmentation hemolysis ... atypical HUS) - Drug-induced ... anemia" • HELLP ... #schistocytes #differential
Drugs Implicated in Hemolytic Anemia • Hapten (Drug binding to RBC membrane): Penicillin, Cephalosporin, Tetracycline, Tolbutamide,
Drugs Implicated ... in Hemolytic Anemia ... #medications #Hemolytic ... #Anemia #differential ... #diagnosis #pharmacology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Corpuscular Volume (MCV ... ) - Differential ... • Bleeding • Hemolysis ... Deficiency • Drugs ... #Differential #
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Corpuscular Volume (MCV ... ) - Differential ... Bleed • Hemolysis ... Microangiopathic Hemolytic ... #Differential #
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
- Differential ... delayed HTR • Drug-induced ... • PNH • Drug-induced ... anemia • ... Extravascular #Differential
Hyperuricemia - Differential Diagnosis Algorithm Primary - Over-production • Increased turnover of nucleotides Primary
Hyperuricemia - Differential ... Myeloid Leukemia (CML ... ) - Hemolytic ... Anemia - Others ... Hyperuricemia #Differential
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Membrane Defects, Drugs ... Defects: Sickle cell anemia ... Urobilinogen #Hemolysis ... #Differential #
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