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diagnosis differential pathophysiology management causes algorithm clinical hematology nephrology pharmacology hepatology signs treatment nejm symptoms table classification covid19 gastroenterology syndrome
Monoclonal Gammopathy Testing Strengths, Weaknesses and Accuracy Compared - SPEP - IFE - FLC
Gammopathy #Testing #Protein ... #Diagnosis #MGRS ... #MGUS #SPEP #IFE
Suggested algorithm for bone marrow biopsy and skeletal imaging in patients with monoclonal gammopathy of undetermined
significance (MGUS ... 1.5 gm/dL) IgM MGUS ... , low-risk MGUS ... (IgG type, M- protein ... 8) light-chain MGUS
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework Hematologic disorder characterized by the presence of either
Significance (MGUS ... IgM MGUS: • Serum ... IgM monoclonal protein ... Serum monoclonal protein ... Urinary monoclonal protein
Causes of Proteinuria - Differential Diagnosis Algorithm Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
Proteinuria >150mg/d protein ... Myeloma • MGUS ... Diabetes • Protein
Amyloidosis Diagnosis 1) Patient presentation • Cardiac-specific signs of amyloidosis: Diastolic heart failure, Heart failure with preserved
significance (MGUS ... neuropathy, atypical MGUS ... of monoclonal protein
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
gamma gap (total protein ... #Gammopathies #MGUS
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Feature A Monoclonal Protein ... • MM • WM • MGUS ... • MGCS • MGRS ... Dermato-neuro syndrome) MGRS
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Elevated Globulin - Protein ... Gap (Total Protein ... • (Total protein ... Gammopathy Include: • MGUS ... #Globulin #Protein
Subtypes of Serum Proteins Pre-albumin (Transthyretin) Albumin Globulins • Alpha-1: Alpha-1 antitrypsin, Serum amyloid A, Ceruloplasmin, Corticosteroid-binding globulin (Transcortin),
Subtypes of Serum Proteins ... Retinol-binding protein ... Ceruloplasmin, Protein ... SatyaPatelMD #Serum #Proteins
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis Neurologic-Centered: (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Significance (MGUS ... Renal-centered (ie "MGRS ... #Significance #MGUS
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