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causes algorithm nephrology management dermatology rheumatology workup disease secondary systemic thrombocytosis aki cancer classification hepatology injury monoclonal myelodysplastic pruritus treatment
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Thrombocytosis): • Acute ... malignancies • Anemia ... Myelodysplastic syndrome ... myeloid leukemia ... #hematology #secondary
Thrombocytosis - Differential Diagnosis Platelet Count > 450 Reactive: • Anemia/blood loss (Fe deficiency) • Infection/Sepsis • Non-infectious
Diagnosis Platelet ... Reactive: • Anemia ... Myelofibrosis • Chronic ... Myeloid Leukemia ... #Platelets #hematology
Hyperuricemia - Differential Diagnosis Algorithm Primary - Over-production • Increased turnover of nucleotides Primary
Hyperuricemia - Differential ... Diagnosis Algorithm ... Myeloid Leukemia ... Myeloid Leukemia ... - Hemolytic Anemia
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Thrombocytosis - Differential ... Diagnosis Algorithm ... Infectious: • Acute ... or Chronic Inflammatory ... Iron deficiency anemia
Cutaneous manifestations associated with myelodysplastic syndrome • Myeloid hemopathy with the most frequent skin lesions (20%)
myelodysplastic syndrome ... • Myeloid hemopathy ... #differential # ... diagnosis #dermatology ... #oncology #clinical
Basophilia - Differential Diagnosis Framework Basophils < 1% of the total white blood cell count Basophils function similarly
Diagnosis Framework ... Disorders: • Chronic ... myeloid leukemia ... myeloid leukemia ... #hematology #basophils
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Management Summary myelo ... cytopenias (usually anemia ... transformation to acute ... Management #treatment #hematology ... #oncology
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
Diagnostic Framework ... disease, Acute ... Myelodysplastic syndrome ... morphologic #mcv #differential ... #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Platelet Count - Differential ... Diagnosis Algorithm ... , deficiency anemia ... Kawasaki, Nephrotic syndrome ... • Infections: Chronic
Etiologies of Peripheral Neuropathy • Metabolic / Nutritional: DiabetesB12 deficiency, Uremia/ESRD, Hypothyroidism • Medication-induced: ART, Antibiotics,
Paraprotein-associated (POEMS syndrome ... Fabry's disease, Acute ... Peripheral #Neuropathy #differential ... #diagnosis #causes ... #neurology
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