30 results
Pathophysiology of Hypocomplementemic Urticarial Vasculitis

C1q/anti-C1q antibiody ->
Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathway Activation (C3a ... and C5a) -> Anaphylatoxins ... Vasculitis + Tissue Damage ... Pathophysiology #Rheumatology
Causes of Thrombocytosis - Differential Diagnosis Algorithm
Spurious:
 • Artifact (redo CBC)
Autonomous:
 • Essential thrombocytosis
 • Polycythemia
disease Tissue Damage ... Non malignant hematologic ... effect following treatment ... states • Non-hematologic ... Algorithm #Causes #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
→ Refer to hematology ... • Nonmalignant hematologic ... Rebound effect from treatment ... infections • Tissue damage ... Diagnosis #Algorithm #hematology
Approach to Gout
Diagnosis: r/o septic arthritis! Needle-shaped, negative birefringent crystals
Treatment:
 • Weight loss, diet, d/c culprit
birefringent crystals Treatment ... Acute and chronic treatment ... ) Radiographic Damage ... diagnosis #management #treatment ... #ULT #rheumatology
Rewarming Methods in Hypothermia
 • Passive rewarming - Requires adequate patient physiologic mechanisms. Inadequate for more
method • Bladder lavage ... warm • Gastric lavage ... • Peritoneal lavage ... Cardiopulmonary bypass or VA-ECMO ... Hypothermia #management #treatment
Warm vs Cold Autoimmune Hemolytic Anemia
Warm Autoimmune Hemolytic Anemia:
 • Mechanism: IgG and Complement-mediated
 • Etiology:
Spherocytes • Treatment ... transient hemolysis • Treatment ... Plasmapheresis - VA ... Hemolytic #Anemia #hematology
Managing warfarin INR

Warfarin dosage must be individualized according to the patient's response to the drug, and
INR Warfarin dosage ... #pharmacology #treatment ... decisionaid #cardiology #hematology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Triggers: ATRA treatment ... and endothelial damage ... and endothelial damage ... Renal Failure Treatment ... diagnosis #management #hematology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Puncture, EEG Treatment ... prevention (statin for CVA ... CNS #neurology #rheumatology ... diagnosis #management #treatment
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
signs of end organ damage ... • Treatment: ... Low calcium • Treatment ... - Hyperkalemia treatment ... diagnosis #management #hematology