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differential management erythematosus lupus sle hemolysis oncology algorithm autoimmune causes disease signs symptoms monoclonal treatment workup autoantibodies classification criteria extravascular
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table Warm AIHA (48-70%) Cold AHA (16-32%) • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic ... Anemia (AIHA) - ... (7-8%) DAT-negative ... #Anemia #AIHA # ... #Table #hematology
Autoimmune Hemolytic Anemia (AIHA) Pathophysiology - Warm vs Cold AIHA Warm AIHA: - 70%; IgG mediated -
Autoimmune Hemolytic ... Anemia (AIHA) Pathophysiology ... C3 positive or negative ... #Autoimmune #Hemolytic ... #diagnosis #hematology
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
Hemolytic Anemias ... - Differential Diagnosis ... Anemias (AIHAs) ... #Diagnosis #Algorithm ... #hematology
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Anemia 1) DIAGNOSE ... AIHA • Anemia ... FOR a cause → Systematic ... #Anemia #diagnosis ... management #treatment #rheumatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... anemia): ... ) - HELLP syndrome ... uremic syndrome ... #hematology #anemia
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
- Differential Diagnosis ... • Cold AIHA ... anemia • ... #Differential #Diagnosis ... Algorithm #Causes #Hematology
Differential diagnosis of schistocytes / fragmentation hemolysis: • Thrombotic microangiopathies (TMA) - TTP
Differential diagnosis ... syndrome (ST-HUS ... anemia" • HELLP ... #differential #diagnosis ... #hematology #hemolysis
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Diagnosis Framework ... Drug-associated, PCH, Evans Syndrome ... Defects: Sickle cell anemia ... #hematology
Expected DAT Results in Autoimmune Hemolysis DAT Negative Hemolysis • DAT Poly ( - ), IgG (
in Autoimmune Hemolysis ... DAT Negative Hemolysis ... ), C3d ( - ) WAIHA ... DAT #Autoimmune #Hemolysis ... #hematology #diagnosis
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... for Hemolytic Anemia ... Hypersplenism • AIHA ... #Diagnosis #causes ... classification #hematology
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