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Bone resorption and the relationship between osteoblasts and osteoclasts. RANK is expressed on the osteoclasts,
Bone resorption ... the surface of bone ... from the adjacent bone ... which results in bone ... #Osteoclasts #Bone
Glucocorticoid-Induced Osteoporosis: Pathogenesis and Clinical Findings • Negative feedback on hypothalamus/pituitary, Decreasing ACTH -> Decr Sex
production of osteoblasts ... and GF's -> Osteoblasts ... -> Incr Osteoclasts ... -> Reduced Bone ... Formation, Increased Bone
Malignant Bone Tumors: Pathogenesis of X-ray appearance • Metastatic bone tumors (aka. cancerous cells from systemic
Malignant Bone Tumors ... • Metastatic bone ... cells activate osteoblasts ... more than osteoclasts ... activate largely osteoclasts
Fracture Healing (and disruptors of this process) Inflammatory Stage (0-7d) • Fracture disrupts local blood vessels ->
cartilaginous matrix by osteoblasts ... forms bony callus ... mos - yrs) • Osteoclast-osteoblast ... coupled bone remodeling ... from GI tract, bone
Pharmacologic Options for Hypercalcemia Associated with Cancer Rehydration with NS followed by loop diuretics • IV normal
acid - Inhibits osteoclast ... activity; decreases bone ... RANKL to decrease osteoclast ... Calcitonin - Inhibits bone ... nitrate - Inhibits osteoclast
Paget’s Disease: Complications Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation MSK
Complications Abnormal Osteoclasts ... cause excessive bone ... turnover -> Incr bone ... Incr (abnormal) bone ... MSK • Deformed bones
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Incr IGF1 • Bone ... IGFIR activates osteoblasts
Bisphosphonates for Osteoporosis Treatment or Prevention Bisphosphonates are common medications used in the treatment and prevention
Bisphosophonates inhibit osteoclasts ... turn increase bone
Complications of Monoclonal Gammopathy of Undetermined Significance (MGUS) Fracture, Osteoporosis - Increased osteoclast activity and bone resorption
Osteoporosis - Increased osteoclast ... activity and bone ... resorption - Bone
Charcot Joint - Neuropathic Arthropathy: Pathogenesis and Clinical findings • Impaired joint protection -> abnormal joint
cytokines act on osteoclasts ... periarticular bone
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