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diagnosis differential rheumatology syndrome oncology algorithm dermatology hemolytic classification encephalopathy nephrology aplastic arterial cns extravascular gastroenterology hemolysis hemophagocytic hepatic hlh
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Causes Intravascular ... hemoglobinuria (PNH ... #Causes #differential ... #diagnosis #hematology ... #anemia
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... • PCH • PNH ... immune-complex hemolytic anemia ... Diagnosis #Algorithm #Causes ... #Hematology
Causes of Arterial and Venous Thrombosis - Differential Diagnosis Framework STRUCTURAL: - PFO: paradoxical emboli - Popliteal
Causes of Arterial ... artery aneurysm: Causes ... - Disseminated intravascular ... neoplasms - PNH ... Diagnosis #clots #hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... disorders • Celiac disease ... effect following treatment ... Iron deficiency anemia ... #Hematology
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
for Hemolytic Anemia ... : • Liver disease ... IVIG infusion Intravascular ... #Hemolytic #Anemia ... classification #hematology
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Aplastic Anemia ... Treatment: • Consider ... • Associated PNH ... #diagnosis #management ... #treatment #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Diagnosis and Management ... old, ~10,000 new cases ... cytopenias (usually anemia ... only curative treatment ... #treatment #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
PT, aPTT(liver disease ... (CVID, WAS), (neurologic ... changes), high MCV anemia ... bypass), LFT (liver disease ... #Workup #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... • Severe Liver Disease ... Treat primary cause ... #treatment #management ... #hematology
Autoimmune Hemolytic Anemia (AIHA) Treatment Warm AIHA: 1) Steroids - 1-2 mg/kg prednisone daily • Until
Autoimmune Hemolytic Anemia ... (AIHA) Treatment ... esp if severe disease ... #AIHA #Treatment ... #management #hematology
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