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Raynaud Phenomenon Differential Diagnosis: Rheumatologic - MCC systemic sclerosis, RA, SLE, Sjogren syndrome, Antisynthetase syndrome, MCTD Heme -
Raynaud Phenomenon ... sclerosis, RA, SLE ... #Diagnosis #Reynaud
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
manifestations • Neonatal SLE ... Anti-UI-ribonucleoprotein - 35% • Raynaud ... dysmotility • MCTD (SLE ... • Specific for SLE ... Erythematosus #SLE
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
pattern: - SLE ... pattern: - SjS, SLE ... SSc, PM/SSc OS, Raynaud ... Speckled: - SLE ... CTD-ILD, IIM, Raynaud
Systemic Lupus Erythematosus (SLE) - Typical Signs/Symptoms Alopecia, Fever, Malar rash, Photosensitivity, Adenopathies, Lupus pneumonia, Pleurisy, Pancreatitis,
Erythematosus (SLE ... Lupus enteritis, Raynaud's ... Erythematosus #SLE
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Highly specific for SLE ... Association with both SLE ... with MCTD and Raynaud's ... Anti-Ribo-P 5-15% If SLE ... higly specific for SLE
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Systemic Lupus (SLE ... defect (rare) Raynaud's ... Thrombocytopenia #Lupus #SLE
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Photosensitivity 29% - Raynaud's ... involvement 3% SLE-Related ... Lupusreference #SLE
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... Reticularis, Vasculitis, Raynaud's ... Phenomenon #Lupus #SLE
Antinuclear Antibody Testing Cytoplasmic Patterns Reticular/AMA: • PBC, SSc, PBC/SSc OS, PBC/SjS OS • AMA Speckled: •
AMA Speckled: • SLE ... CTD-ILD, IIM, Raynaud ... conditions, SjS, SLE ... Golgi/polar: • SLE
Raynaud's Syndrome - Washing off under hot water. Raynaud phenomenon is an exaggerated vasoconstrictive response of the
Raynaud's Syndrome ... Raynaud phenomenon ... #Raynauds #Syndrome
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