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Raynaud Phenomenon Differential Diagnosis: Rheumatologic - MCC systemic sclerosis, RA, SLE, Sjogren syndrome, Antisynthetase syndrome, MCTD Heme -
Raynaud Phenomenon ... Differential Diagnosis ... sclerosis, RA, SLE ... - Frostbite #Diagnosis ... #Reynaud #Phenomenon
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Anti-UI-ribonucleoprotein - 35% • Raynaud ... dysmotility • MCTD (SLE ... • Specific for SLE ... Erythematosus #SLE ... #Summary #diagnosis
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
pattern: - SLE ... pattern: - SjS, SLE ... SSc, PM/SSc OS, Raynaud ... CTD-ILD, IIM, Raynaud ... #differential #diagnosis
Systemic Lupus Erythematosus (SLE) - Typical Signs/Symptoms Alopecia, Fever, Malar rash, Photosensitivity, Adenopathies, Lupus pneumonia, Pleurisy, Pancreatitis,
Erythematosus (SLE ... Lupus enteritis, Raynaud's ... Erythematosus #SLE ... Signs #Symptoms #diagnosis
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Systemic Lupus (SLE ... defect (rare) Raynaud's ... Thrombocytopenia #Lupus #SLE ... signs #symptoms #diagnosis
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Highly specific for SLE ... Association with both SLE ... with MCTD and Raynaud's ... higly specific for SLE ... erythematosus #diagnosis
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Erythematosus - Diagnosis ... Photosensitivity 29% - Raynaud's ... involvement 3% SLE-Related ... Differential Diagnosis ... Lupusreference #SLE
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... Reticularis, Vasculitis, Raynaud's ... Phenomenon #Lupus #SLE ... pathophysiology #diagnosis
Antinuclear Antibody Testing Cytoplasmic Patterns Reticular/AMA: • PBC, SSc, PBC/SSc OS, PBC/SjS OS • AMA Speckled: •
AMA Speckled: • SLE ... CTD-ILD, IIM, Raynaud ... conditions, SjS, SLE ... Golgi/polar: • SLE ... #differential #diagnosis
Antinuclear Antibody Testing - Nuclear Patterns Homogeneous pattern: • SLE, SSc, AIH, JIA • dsDNA, chromatin,
Homogeneous pattern: • SLE ... pattern: • SjS, SLE ... SSc, PM/SSc OS, Raynaud ... #differential #diagnosis
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