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diagnosis differential algorithm nephrology management potassium hypokalemia cardiology hypercalcemia low signs symptoms workup adrenal neurology tls treatment alkalosis hyperuricemia hypocalcemia
Pathophysiology of Tumor Lysis Syndrome (TLS) Tumor Cell Lysis -> Release of DNA • Purines -> Hypoxanthine /
Pathophysiology ... of Tumor Lysis Syndrome ... -> Allantoin (High ... Hypocalcemia • Hyperkalemia ... #TLS #Pathophysiology
Causes of Hypercalcemia Hypercalcemia due to increased bone Ca2+ resorption: • Primary hyperparathyroidism, Malignancy, Pseudohyperparathyroidism, Renal failure,
Causes of Hypercalcemia ... calcium)-alkali syndrome ... #Causes #differential ... diagnosis #calcium #high ... #endocrinology
Hypokalemia - Differential Diagnosis Algorithm Extra-renal Losses: • Normal Acid-Base: Low intake • Metabolic acidosis: Gl tract
Hypokalemia - Differential ... • HTN, High Aldosterone ... Renin secreting tumor ... @priti899 #Hypokalemia ... Diagnosis #Algorithm #causes
Causes of HyperKalemia - Differential Diagnosis Increased extracellular K+: • Tissue injury • Hemolysis • Rhabdomyolysis •
Causes of HyperKalemia ... Rhabdomyolysis • Tumor ... lysis syndrome ... glycosides • High ... MCW_Nephrology #HyperKalemia
Hypokalemia Differential Diagnosis Algorithm Hypertensive: • High Al, Low R - Primary aldosteronism • High Al, High
Hypokalemia Differential ... Hypertensive: • High ... Renin-secreting tumor ... #Hypokalemia # ... Algorithm #nephrology #causes
Hyperkalemia Differential Diagnosis Algorithm R/O Pseudo-hyperkalemia: • Possible Lab error! Alwavs Repeat Blood sample! • Leukocytosis, Thrombocytosis:
Hyperkalemia Differential ... TTKG should be high ... Diagnosis #Algorithm #causes ... #potassium #high ... #pathophysiology
Causes of Hypokalemia - Differential Diagnosis Algorithm Defining the cause of hypokalemia starts by measuring urinary K
Causes of Hypokalemia ... Defining the cause ... of hypokalemia ... Renin-secreting tumor ... diagnosis #algorithm #causes
Causes of Hypercalcemia Parathyroid hormone–dependent Primary hyperparathyroidism Familial hypocalciuric hypercalcemia Lithium-associated Tertiary hyperparathyroidism Genetic disorders (e.g., multiple endocrine neoplasia type 1 or
Causes of Hypercalcemia ... hypocalciuric hypercalcemia ... Other humoral syndromes ... #Causes #Differential ... #Diagnosis #Endocrinology
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 Hypercalcemia - Differential Diagnosis Algorithm Elevated PTH (High or normal): • Primary Hyperparathyroidism • Familial Hypocalciuric Hypercalcemia Low
Hypercalcemia - ... Elevated PTH (High ... Hypocalciuric Hypercalcemia ... Diagnosis #Algorithm #causes ... #endocrinology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... immature blasts and high ... WBC count cause ... • Pathophysiology ... hydration - Hyperkalemia
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