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diagnosis differential causes hemolysis hepatopulmonary deficiency dermatology extravascular hypercoagulable intravascular rheumatology workup agglutinin antiphospholipid apls b12 bilirubinemia cancer cirrhosis clinical
Differential diagnosis of schistocytes / fragmentation hemolysis: • Thrombotic microangiopathies (TMA) - TTP
syndrome (ST-HUS ... formerly known as ... anemia" • HELLP ... syndrome • Catastrophic ... differential #diagnosis #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... (HUS) • Other ... ) (e.g. lupus, CLL ... differential #diagnosis #hematology ... #anemia
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Differential Diagnosis Algorithm ... anemia • ... MAHA (TTP, DIC, HUS ... Differential #Diagnosis #Algorithm ... #Causes #Hematology
Hepatopulmonary Syndrome (HPS) HPS-differential diagnosis: 1. Pulmonary vasculature 2. Diseases of the lung parenchyma 3. Pleura and diaphragm HPS-diagnosis: 1. Patients
Hepatopulmonary Syndrome ... Pleura and diaphragm ... Alveolar-arterial ... Hepatopulmonary #Syndrome ... #HPS #hepatology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Thrombosis vs Arterial ... • Nephrotic Syndrome ... • Cardiac: - Atrial ... thrombus - atrial ... pathophysiology #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... blood loss, Acute hemolysis ... , deficiency anemia ... Kawasaki, Nephrotic syndrome ... #hematology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Megakaryopoiesis • Aplastic Anemia ... ITP • SLE • CLL ... Non-lmmune: • HELLP Syndrome ... • TTP/HUS • ... #Causes #Hematology
Iron Deficiency Anemia - Differential Diagnosis Algorithm Labs: Ferritin, iron, transferrin, TIBC, TSAT, sTfR • Blood loss:
Iron Deficiency Anemia ... extravascular) hemolysis ... Gastrectomy, WHDA syndrome ... Bypass surgery, Bacterial ... #ferritin #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... • Symptoms of anemia ... anemia • Cold ... , Myeloma • Waldenström ... #anemia #hematology
Approach to the Hypercoagulable State Arterial thromboembolism → Cardiac rhythm monitoring, Echocardiogram, Vascular imaging → Test for APS, particularly
Hypercoagulable State Arterial ... risk actor for arterial ... Hypercoagulable #Workup #hematology ... #diagnosis #algorithm ... #hematology #VTE
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