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management oncology differential algorithm causes anticoagulation comparison workup hasbled hemeonc leukemia syndrome afib aplastic bleed cancer chads2 chads2vasc chronic classification
Bleeding risk calculators - HAS-BLED (atrial fibrillation) and IMPROVE (VTE prophylaxis for inpatients) Important notes: • No
Bleeding risk calculators ... risk tools have ... validated for VTE treatment ... Anticoagulation #Factors #Hematology ... #Diagnosis
Stroke and bleeding risk stratification with the CHADS2-VASc and HAS-BLED schemas #Diagnosis #Hematology #CHADS2 #CHADS2VASc #HASBLED #Comparison
Stroke and bleeding ... risk stratification ... HAS-BLED schemas #Diagnosis ... #Hematology #CHADS2 ... Comparison #Score #Risk
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 Approach to Leukocytosis - Differential Diagnosis Algorithm Features of hematologic malignancy: • Symptoms: B-symptoms, bruising/bleeding, fatigue/weakness, immunosuppression
- Differential Diagnosis ... Features of hematologic ... B-symptoms, bruising/bleeding ... hepatomegaly • Labs: anemia ... #Algorithm #hematology
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
neutropenia • Mucosal bleeding ... Diagnosis: • Pancytopenia ... Treatment: • Consider ... #diagnosis #management ... #treatment #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
cytopenias (usually anemia ... and risk-stratification ... • Risks: infection ... #Management #treatment ... #hematology #oncology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
- Differential Diagnosis ... → Refer to hematology ... hemolysis, deficiency anemia ... Rebound effect from treatment ... #Algorithm #hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
- Differential Diagnosis ... effect following treatment ... Iron deficiency anemia ... #Differential #Diagnosis ... Algorithm #Causes #Hematology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Causes of Anemia ... - Differential Diagnosis ... 80-100 fL) • Bleeding ... #Differential #Diagnosis ... Algorithm #Causes #Hematology
Von Willebrand Disease - Most common inherited bleeding disorder Clinical • Easy bruising •
common inherited bleeding ... • Prolonged bleeding ... factor VIII) Treatment ... VonWillebrand #Disease #Diagnosis ... #Hematology
Warm vs Cold Autoimmune Hemolytic Anemia Warm Autoimmune Hemolytic Anemia: • Mechanism: IgG and Complement-mediated • Etiology:
Autoimmune Hemolytic Anemia ... Autoimmune Hemolytic Anemia ... Spherocytes • Treatment ... transient hemolysis • Treatment ... #hematology #diagnosis
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