53 results
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
hemolysis, deficiency anemia ... Rebound effect from treatment ... TPO, TPO-RA • Infections ... : Chronic infections ... and viral infections
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
cytopenias (usually anemia ... risk-stratification • Risks: infection ... transformation to acute ... #treatment #hematology ... #oncology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm
Reactive:
 - Systemic Inflammatory
     •
Pseudotumor - Infectious ... History of Bleeding, Infection ... Fatigue • Acute ... Algorithm #Causes #Hematology ... #Oncology
Aplastic Anemia - Illness Script
Signs and symptoms:
 • Recurrent infections from neutropenia
 • Mucosal bleeding from
: • Recurrent infections ... Treatment: • Consider ... progress to MDS or acute ... #diagnosis #management ... #treatment #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor
The maturation factor is
(e.g. cancer, infection ... Index > 3: • Acute ... G6PD deficiency), Infections ... Production #Index #hematology ... #anemia #differential
Causes of Thrombocytosis - Differential Diagnosis Algorithm
Spurious:
 • Artifact (redo CBC)
Autonomous:
 • Essential thrombocytosis
 • Polycythemia
Thrombocytosis - Differential ... Myelofibrosis Infectious ... : • Acute or Chronic ... effect following treatment ... Iron deficiency anemia
Causes of Thrombocytosis - Differential Diagnosis
Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis):
 • Acute infection
 • Solid organ
Thrombocytosis - Differential ... Thrombocytosis): • Acute ... infection • Solid ... malignancies • Anemia ... Diagnosis #Causes #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Intravascular Hemolysis - Differential ... circulation - Infections ... immune-complex hemolytic anemia ... • Acute HTR ... Algorithm #Causes #Hematology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Neutropenia - recurrent infections ... Idiopathic • Infections ... Treatment: ... #oncology #hematology ... #diagnosis #management
Autoimmune Hemolytic Anemia (AIHA) Treatment
Warm AIHA:
1) Steroids - 1-2 mg/kg prednisone daily
   • Until
Autoimmune Hemolytic Anemia ... (AIHA) Treatment ... Polyclonal: - Infection ... #AIHA #Treatment ... #management #hematology