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Clinical Manifestations of Systemic Lupus Erythematosus (SLE)

#Systemic #Lupus #Erythematosus #SLE #Manifestations #Signs #Symptoms #Rheumatology #Diagnosis
Erythematosus (SLE ... Erythematosus #SLE ... Manifestations #Signs ... #Symptoms #Rheumatology ... #Diagnosis
SLICC SLE Diagnostic Criteria - Systemic Lupus Erythematosus
Clinical and Immunologic Criteria

CLINICAL CRITERIA
 - ACUTE CUTANEOUS LUPUS
SLICC SLE Diagnostic ... (<1000/MM3) - THROMBOCYTOPENIA ... Direct Coombs’ test ... #Rheumatology # ... SLE #Lupus #Erythematosus
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Neurological 12% - Thrombocytopenia ... involvement 3% SLE-Related ... Lupusreference #SLE ... autoantibodies #signs ... #differential #rheumatology
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Leucopenia/lymphopenia, Thrombocytopenia ... #Lupus #SLE #systemic ... erythematosus #signs ... #symptoms #diagnosis ... #rheumatology
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Systemic Lupus Erythematosus ... Initial screening test ... #Summary #diagnosis ... #rheumatology # ... management
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus
Clinical Domains:
 • Constitutional domain: Fever
 • Cutaneous domain: Non-scarring
pericarditis • Hematologic ... domain: Leukopenia, Thrombocytopenia ... Classification #Criteria #SLE ... Erythematosus #diagnosis ... #rheumatology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... (SLE) - Diagnosis ... and Management ... Erythematosus #Diagnosis ... #rheumatology
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
Farr assay) and lupus ... , neonatal lupus ... clinically suspected, tests ... erythematosus #diagnosis ... #rheumatology #
Hydroxychloroquine Serum Measurement in SLE
 • Terminal elimination half-life = 40 days ([HCQI reflects long-term intake)
Measurement in SLE ... if < 200ng/mL Best ... #rheumatology # ... pharmacology #levels #lupus ... #management
Systemic Lupus Erythematosus (SLE) - Typical Signs/Symptoms
Alopecia, Fever, Malar rash, Photosensitivity, Adenopathies, Lupus pneumonia, Pleurisy, Pancreatitis,
(SLE) - Typical ... Signs/Symptoms ... Erythematosus #SLE ... #Signs #Symptoms ... #diagnosis #rheumatology