52 results
hematology differential management causes algorithm oncology infectiousdiseases workup erythematosus leukemia lupus pulmonary reactions sle systemic atlas autoimmune chronic cll deficiency
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Anemia 1) DIAGNOSE ... type ± C3d • Blood ... #Anemia #diagnosis ... #management #treatment ... #rheumatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... anemia): ... spherocytosis) • Infections ... #differential #diagnosis ... #hematology #anemia
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
Hemolytic Anemia ... - Differential Diagnosis ... • Peripheral blood ... malignancy, autoimmune disease ... Fevers, DAT (-) → Infection
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
Chronic kidney disease ... (e.g. cancer, infection ... Microangiopathic hemolytic ... G6PD deficiency), Infections ... #diagnosis #calculation
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Red Blood Cell ( ... , McLeod blood group ... Microangiopathic Hemolytic ... #differential #diagnosis ... #hematology #microscopy
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
- Differential Diagnosis ... • Bleeding • Hemolysis ... Inflammation, Chronic Infection ... #MCV #Classification ... Algorithm #Causes #Hematology
Autoimmune Hemolytic Anemia (AIHA) Treatment Warm AIHA: 1) Steroids - 1-2 mg/kg prednisone daily • Until
Anemia (AIHA) Treatment ... esp if severe disease ... Polyclonal: - Infection ... #Anemia #AIHA # ... #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Diagnosis: • hemolytic ... Immunoglobulin M (IgM) • Blood ... sensitize red blood ... #hemolytic #anemia ... #hematology #diagnosis
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
for Hemolytic Anemia ... Causes: • Liver disease ... drug induced • Infections ... #classification ... #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
hematologic: Acute blood ... loss, Acute hemolysis ... , deficiency anemia ... Rebound effect from treatment ... Vasculitides, IBD, Celiac disease
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