23 results
Warm Antibody Autoimmune Hemolytic Anemia 
1) DIAGNOSE AIHA
 • Anemia: macrocytic > normocytic, ↑ reticulocytes
 •
Anemia 1) DIAGNOSE ... AIHA • Anemia ... type ± C3d • Blood ... #management #treatment ... #rheumatology
Autoimmune Hemolytic Anemia (AIHA) Treatment
Warm AIHA:
1) Steroids - 1-2 mg/kg prednisone daily
   • Until
Anemia (AIHA) Treatment ... esp if severe disease ... Polyclonal: - Infection ... Treatment #management ... #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor
The maturation factor is
Chronic kidney disease ... (e.g. cancer, infection ... Microangiopathic hemolytic ... G6PD deficiency), Infections ... Production #Index #hematology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Low Mean Corpuscular Volume (<80
Causes of Anemia ... • Bleeding • Hemolysis ... Inflammation, Chronic Infection ... #MCV #Classification ... Algorithm #Causes #Hematology
Differential Diagnosis for Hemolytic Anemia
Intrinsic Causes:
 • Enzyme deficiencies ex. G6PD, pyruvate kinase 
 • Hemoglobinopathies
Anemia Intrinsic ... Causes: • Liver disease ... drug induced • Infections ... Diagnosis #causes #classification ... #hematology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
anemia • Cold ... Immunoglobulin M (IgM) • Blood ... sensitize red blood ... #hemolytic #anemia ... #hematology #diagnosis
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
hematologic: Acute blood ... loss, Acute hemolysis ... , deficiency anemia ... Rebound effect from treatment ... Vasculitides, IBD, Celiac disease
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... , Drugs, Liver Disease ... Internal (RBC) - Infections ... Defects: Sickle cell anemia ... - Peripheral Blood
Listeriosis Summary - Listeria Monocytogenes
Pathogen: Listeria Monocytogenes - Gram-positive rod, Aerobic, facultative anaerobe, motile, beta-hemolytic, Non-spore-forming
Risk
, motile, beta-hemolytic ... available • Blood ... ) • CSF (CNS Infection ... Monocytogenes #diagnosis #management ... infectiousdiseases #treatment
Listeriosis Summary - Listeria Monocytogenes
Pathogen: Listeria Monocytogenes - Gram-positive rod, Aerobic, facultative anaerobe, motile, beta-hemolytic, Non-spore-forming
Risk
, motile, beta-hemolytic ... available • Blood ... ) • CSF (CNS Infection ... Monocytogenes #diagnosis #management ... infectiousdiseases #treatment