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diagnosis management differential pharmacology rheumatology algorithm treatment causes table medications clinical nephrology neurology comparison hematology dermatology pathophysiology pulmonary endocrinology lupus
Anti-GIomeruIar Basement Membrane Disease (Goodpasture's Disease) What is it? A small vessel vasculitis with circulating antibodies directed
Anti-GIomeruIar ... Membrane Disease (Goodpasture's ... Diagnosis: • Anti-GBM ... @PulmPEEPs #Anti ... Membrane #Disease #Goodpastures
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
- SLE Anti-histone ... (AMA), Anti-sp100 ... - SLE Anti-SSA ... (Ro), Anti-SSB ( ... - Goodpasture's
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Henoch-SchonIein Purpura Anti-GBM ... Limited to Kidney: Anti-GBM ... pulmonary involvement: Anti-GBM ... Disease (Goodpasture's
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
sclerosis • Anti-Glomerular ... Basement Membrane: Goodpasture's ... Disease-specific testing: anti-ANCA ... ab, anti-GBM ab ... , ANA, C3, C4, anti-CCP
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
polyangiitis) Anti-basement ... membrane: Goodpasture ... ANCA antibody, Anti-GBM ... usually low in anti-GBM ... FINDINGS: • AAV or Goodpasture's
Main types of autoimmune encephalitis in the ICU. Anti-NMDAR anti-N-methyl-d-aspartate receptor, ADEM acute disseminated encephalomyelitis, Anti-GFAP
Anti-NMDAR anti-N-methyl-d-aspartate ... anti-glial fibrillary ... anti-gamma aminobutyric ... anti-gamma aminobutyric ... anti-leucine-rich
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Lupus (SLE): ANA (anti-nuclear ... , Anti-Ro (SSA) ... and Anti-La (SSB ... (SSA), Anti-La ... (SSB) • MCTD: Anti-UI
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Anti-dsDNA (in 70% ... Anti-Sm (Smith) ... Anti-histone (in ... Anti-Ro/SSA ... Anti-La/SSB •
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
60-70% - Anti-SSA ... 30-40% - Anti-SSB ... 5-10% - Anti- ... 5-15% - Anti-Ku ... 5-10% - Anti-PCNA
Hemoptysis - Differential Diagnosis Framework Airways: • Bronchitis • Bronchiectasis • Malignancy: Primary bronchogenic CA, Endobronchial
Rheumatic/lmmune: Goodpastures
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