1205 results
Intracranial Hemorrhage (ICH) and Increased Intracranial Pressure (ICP) - Pathophysiology
ICH Management:
1. Manage Blood Pressure
  •
) - Pathophysiology ... ICH Management ... • Spontaneous ICH ... High ICP: 20. ... #Pathophysiology
Pathophysiology of Hypocomplementemic Urticarial Vasculitis

C1q/anti-C1q antibiody ->
Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology ... Mast Cells -> Incr ... inflammatory cells -> Incr ... Vasculitis #HUV #Pathophysiology
Cushing's Reflex - Pathophysiology
HYPERTENSION with a reflex BRADYCARDIA
 → ↑ ICP 
 → ↓ CBF
 →
Cushing's Reflex - Pathophysiology ... BRADYCARDIA → ↑ ICP ... Cushings #Reflex #Pathophysiology
Mechanisms Driving Increased Thrombosis and Bleeding in Liver Disease
Increased Thrombosis 
Increased Platelet-Vesset Wall Interaction 
 •
Interaction • Incr ... Willebrand factor • Incr ... Generation • Incr ... Plasminogen • Incr ... Clot #Cirrhosis #Pathophysiology
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
JAK-STAT pathway -> Incr ... chondrocytes -> Incr ... AKT pathway -> Incr ... strength - Incr ... endocrinology #pathophysiology
Primary Hyperthyroidism - Pathogenesis and Clinical Findings

Note: Although rare, gestational diseases can lead to thyrotoxicosis due
attention - Incr ... intolerance - Incr ... appetite - Incr ... endocrinology #pathophysiology
Oxyhemoglobin Dissociation Curve 

Left Shift - decreased unloading of O2 at tissue level (i.e.  increased
affinity) - incr ... acidosis) - incr ... temperature - incr ... Dissociation #Curve #Pathophysiology
Serotonin-Norepinephrine Reuptake Inhibitors(SNRIs): Mechanisms and Side Effects

Withdrawal: Dizziness, Diarrhea, Insomnia, Nausea, Vomiting
Serotonin Syndrome - Potentially Life
Agitation, Akathisia Incr ... , Weight gain Incr ... SerotoninNorepinephrine #Inhibitors #Pathophysiology
Obesity in the Critically Ill is quite the problem. It worsens the prognosis in our ICU
prognosis in our ICU ... illness #critical #pathophysiology
Bipolar Disorder: Pathogenesis and Clinical Findings
 • Disruption of emotional homeostasis
 • Oscillation between mood states
euphoria - Incr ... grandiosity - Incr ... irritability - Incr ... withdrawal - Incr ... MoodDisorders #Diagnosis #Pathophysiology