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differential lupus erythematosus management systemic causes autoimmune druginduced hemolytic signs symptoms thrombocytosis workup activation autoantibodies cancer chronic cll cold dil
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
- Differential Diagnosis ... Algorithm Spurious ... effect following treatment ... Iron deficiency anemia ... #Hematology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
- Differential Diagnosis ... Algorithm Decreased ... RA, SLE, PRV, Chronic ... #Algorithm #Causes ... #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
- Differential Diagnosis ... → Refer to hematology ... hemolysis, deficiency anemia ... Rebound effect from treatment ... #Algorithm #hematology
Warm vs Cold Autoimmune Hemolytic Anemia Warm Autoimmune Hemolytic Anemia: • Mechanism: IgG and Complement-mediated • Etiology:
Autoimmune Hemolytic Anemia ... Spherocytes • Treatment ... transient hemolysis • Treatment ... #hematology #diagnosis ... #comparison
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
- Differential Diagnosis ... Algorithm Decreased ... Megakaryopoiesis • Aplastic Anemia ... Autoimmune • ITP • SLE ... #Hematology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Systemic Lupus (SLE ... Photosensitivity, Butterfly rash ... ) Blood (75%): Anemia ... signs #symptoms #diagnosis ... #rheumatology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
) - Diagnosis and ... Manifestations: Malar rash ... life-threatening • Treatment ... Erythematosus #Diagnosis ... Management #Summary #rheumatology
Autoimmune Myositis Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
can present with rash ... including heliotrope rash ... Can also see mechanics ... after 2 years of treatment ... #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
NPSLE rare, Malar rash ... Manifestations: Malar rash ... #comparison #table ... #rheumatology # ... diagnosis #management
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
69% - Malar rash ... - Hemolytic anemia ... involvement 3% SLE-Related ... Lupusreference #SLE ... #differential #rheumatology
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