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diagnosis management antifungal candida infectiousdiseases pharmacology antibiotics treatment auris candidemia candidiasis fungal fungemia overview polyenes review abelcet ambisome amphoterecinb anidulafungin
Antifungal Echinocandins - Antibiotics Class Overview Mechanism: Inhibit glucan synthesis in fungal cell wall by blocking
Antifungal Echinocandins ... monotherapy) All Echinocandins ... Review #Overview #Echinocandins
Antifungal Coverage Activity Antibiogram Spectrum of action of systemic antifungal agents. Solid blocks represent species in
Triazoles #Polyenes #Echinocandins
Antibiotics and CNS Diffusion 1. Drugs with good CNS diffusion: - Fluoroquinolones, Fluconazole, voriconazole, Rifampin, Oxazolidinones, Metronidazole 2. Drugs
infections: - Echinocandins
Antifungal Polyenes - Amphoterecin B, Abelcet, Ambisome - Antibiotics Class Overview Mechanism: binds ergosterol in membrane and
infections – because echinocandins
Invasive Candidiasis (IC) Diagnosis: Culture: • Gold standard, but Slow (~2-3 days), 50% sensitivity • Blood Sample •
with AFST) • Echinocandin
Candidemia Workup and Management - IDSA Guidelines 1) Antibiotics • Empiric: Echinocandins (e.g. micafungin) for most patients
Antibiotics • Empiric: Echinocandins
Causes of Hypokalemia Transcellular Shifts: - Alkalosis, Increased plasma insulin (treatment of diabetic ketoacidosis), ß-Adrenergic agonists, Hypokalemic
aminoglycosides, echinocandins
Pulmonary Histoplasmosis Quick Facts on Histoplasma capsulatum: • Dimorphic fungi, in yeast phase within the body •
• Resistant to echinocandins
Management of Suspected and Confirmed Candida auris Isolate patients with suspected C auris • Private
therapy with an echinocandin
Candida Glabrata Species of Candida Most Commonly Isolated in Bloodstream Infections • Symptomatic mucosal infection is detected
option, consider echinocandin
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