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diagnosis pathophysiology endocrinology signs symptoms complications management osteoporosis pharmacology arthropathy bisphosphonates bone bonetumors bony charcotjoint disruptors dosing drugs feedbackloop fracture
Bone resorption and the relationship between osteoblasts and osteoclasts. RANK is expressed on the osteoclasts,
relationship between osteoblasts ... and osteoclasts ... expressed on the osteoclasts ... RANK stimulates osteoclast ... #Osteoclasts #Bone
Glucocorticoid-Induced Osteoporosis: Pathogenesis and Clinical Findings • Negative feedback on hypothalamus/pituitary, Decreasing ACTH -> Decr Sex
production of osteoblasts ... and GF's -> Osteoblasts ... expression of osteoclasts ... -> Incr Osteoclasts
Malignant Bone Tumors: Pathogenesis of X-ray appearance • Metastatic bone tumors (aka. cancerous cells from systemic
cells activate osteoblasts ... more than osteoclasts ... activate largely osteoclasts
Fracture Healing (and disruptors of this process) Inflammatory Stage (0-7d) • Fracture disrupts local blood vessels ->
cartilaginous matrix by osteoblasts ... mos - yrs) • Osteoclast-osteoblast ... gentamycin - Toxic to osteoblasts
Pharmacologic Options for Hypercalcemia Associated with Cancer Rehydration with NS followed by loop diuretics • IV normal
acid - Inhibits osteoclast ... RANKL to decrease osteoclast ... nitrate - Inhibits osteoclast
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
IGFIR activates osteoblasts
Bisphosphonates for Osteoporosis Treatment or Prevention Bisphosphonates are common medications used in the treatment and prevention
Bisphosophonates inhibit osteoclasts
Charcot Joint - Neuropathic Arthropathy: Pathogenesis and Clinical findings • Impaired joint protection -> abnormal joint
cytokines act on osteoclasts
Complications of Monoclonal Gammopathy of Undetermined Significance (MGUS) Fracture, Osteoporosis - Increased osteoclast activity and bone resorption
Osteoporosis - Increased osteoclast
Paget’s Disease: Complications Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation MSK
Complications Abnormal Osteoclasts
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